Article de journal
A proposed mechanism of action of the inotropic agent digitalis


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Détails sur la publication
Liste des auteurs: V. A. Knight
Editeur: Elsevier
Année de publication: 1981
Journal: Medical Hypotheses
Nom du journal dans la source: MEDICAL HYPOTHESES
Numéro du volume: 7
Numéro de publication: 5
Page d'accueil: 669
Dernière page: 672
Nombre de pages: 4
ISSN: 0306-9877
Web of Science ID: A1981LX71100013
PubMed-ID: 6268950
Scopus ID: 0019830105


A theory based on hydrogen bonded water structure is put forward to explain the action of digitalis and other cardiac glycosides on cardiac tissue. The activity of free Ca++ is altered when the Na+ + K+ ATPase is inhibited, and there results a redistribution between sarcoplasm and other calcium pools.


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