Journal article
A Method for Reconstruction of Severely Damaged Spinal Cord using Autologous Hematopoietic Stem Cells and Platelet‑rich Protein as a Biological Scaffold

Research Areas
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Publication Details
Author list: Ahmed Sabry Ammar, Yasser Osman, Ahmed Taher Hendam, Mohammed Ahmed Hasen, Fatma Abdullah Al Rubaish, Danya Yaagoub Al Nujaidi, Faisal Mishal Al Abbas
Publisher: Medknow Publications
Publication year: 2017
Journal: Asian Journal of Neurosurgery
Journal acronym: AJNS
Volume number: 12
Issue number: 4
Start page: 681
End page: 690
Number of pages: 10
ISSN: 1793-5482
Web of Science ID:
PubMed ID: 29114283
Scopus ID:
eISSN: 2248-9614
Languages: English-United States

Introduction: There have been attempts to alter the prognosis of severe spinal cord injury in

different centers, but none of which have reliably altered the outcome. Some trials use stem cells

(SCs) that produced widely differing results. We hereby add our experience in our center of a

surgical reconstruction of the damaged spinal cord using a mixture of SCs and Platelet-Rich Protein

(PRP) with fibrin coated as a biological scaffold. Materials and Methods: Four cases of severely

damaged spinal cord have been operated for neurolysis and reconstruction of the spinal cord using

SCs and platelet‑rich protein (PRP) with fibrin coated harvested from the peripheral circulation of

the patient. PRP serves to maintain the position of the SCs. One milliliter suspension contains an

average of 2.8 × 106 of autologous hematopoietic SCs. Patients were intraoperatively monitored

by somatosensory evoked potential, motor evoked potentials, and delta wave. They are clinically

followed postoperatively and electromyogram was repeated every 2 weeks. Magnetic resonance

imaging (MRI) was repeated regularly. The patients are followed up for a period between 2 and

3 years. Results: One patient demonstrated motor and objective sensory improvement (P = 0.05),

two other patients reported subjective sensory improvement, and the fourth one remained without

any improvement (P = 0.1). None of these patients demonstrated any sign of deterioration or

complication either on the surgery or on implanting of the SCs. MRI clearly proved that the inserted

biological scaffold remained in place of reconstruction. Conclusion: SCs may play a role in restoring

spinal cord functions. However, the unsolved problems of the use of SCs and related ethical issues

should be addressed.

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Last updated on 2020-10-12 at 09:56