Journal article
6-shogaol, a active constiuents of ginger prevents UVB radiation mediated inflammation and oxidative stress through modulating NrF2 signaling in human epidermal keratinocytes (HaCaT cells)


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Author list: Feng Chen, Ying Tang, Yujia Sun, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan and Chuanxin Cui
Publisher: Elsevier
Publication year: 2019
Journal: Journal of Photochemistry and Photobiology B: Biology
Volume number: 197
Issue number: August 2019
Start page: 1
End page: 7
Number of pages: 7
ISSN: 1011-1344
Web of Science ID:
PubMed ID:
Scopus ID: 85067006367
eISSN: 1873-2682


Disclosure of ultraviolet (UV) radiation is the key feature from environment to cause redness of the skin, inflammation, photoaging and skin cancer. 6-Shogaol, a spicy compound secluded from ginger, which shows anti-inflammatory effects. Present study was demonstrated the role of 6-Shogaol on UVB induced oxidative stress and photoaging signaling in human epidermal keratinocytes (HaCaT cells). In this study, UVB-irratiation (180 mJ/cm2) significantly elevated the intracellular ROS levels, depletion of antioxidants resulted in apoptotic HaCaT cells. MAPKs signaling are concerned in oxidative stress; these signaling events are measured as differentiation. We found that 6-shogaol prevents over expression of MAPKs (ERK1, JNK1 & p38), in disclosure of UVB in HaCaT cells. Moreover, 6-shogaol infringed Bax and Bcl-2 in which 20 μg 6-shogaol influenced apoptosis in HaCaT cells by investigating augmented appearance of Bax and condensed appearance of Bcl-2 in contrast to control HaCaT cells. These results suggest that 6-shogaol could be a successful healing agent provides fortification against UVB-induced provocative and oxidative skin reimbursement.



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Last updated on 2019-28-08 at 10:07