Journal article review
Targeted delivery of miRNA based therapeuticals in the clinical management of Glioblastoma Multiforme

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Publication Details
Author list: Faheem Hyder Pottoo, Noushad Javed, Jawadur Rahman, Tareq Abu-Izneid, and Firdos Alam Khan
Publisher: Elsevier: 12 months
Publication year: 2021
Journal: Seminars in Cancer Biology
Volume number: 69
Issue number: February 2021
Start page: 391
End page: 398
Number of pages: 8
ISSN: 1044-579X
Web of Science ID:
PubMed ID: 32302695
Scopus ID: 85084332758
eISSN: 1096-3650

Glioblastoma multiforme (GBM) is the most aggressive (WHO grade IV) form of diffuse glioma endowed with tremendous invasive capacity. The availability of narrow therapeutic choices for GBM management adds to the irony, even the post-treatment median survival time is roughly around 14-16 months. Gene mutations seem to be cardinal to GBM formation, owing to involvement of amplified and mutated receptor tyrosine kinase (RTK)-encoding genes, leading to dysregulation of growth factor signaling pathways. Of-late, the role of different microRNAs (miRNAs) in progression and proliferation of GBM was realized, which lead to their burgeon potential applications for diagnostic and therapeutic purposes. miRNA signatures are intricately linked with onset and progression of GBM. Although, progression of GBM causes significant changes in the BBB to form BBTB, but still efficient passage of cancer therapeutics, including antibodies and miRNAs are prevented, leading to low bioavailability. Recent developments in the nanomedicine field provide novel approaches to manage GBM via efficient and brain targeted delivery of miRNAs either alone or as part of cytotoxic pharmaceutical composition, thereby modulating cell signaling in well predicted manner to promise positive therapeutic outcomes.

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Last updated on 2021-21-03 at 09:13