Journal article
Adaptation and Validation of the Mini-Addenbrooke's Cognitive Examination in Dementia in Arabic Speakers in Egypt

Research Areas
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Publication Details
Author list: Qassem T. · Khater M.S. · Emara T. · Rasheedy D. · Tawfik H.M. Mohammedin A.S. · Tolba M.F. · Saber H.G. · Aly El-Gabry D. · Abdel Aziz K
Publisher: Karger Publishers
Publication year: 2021
Journal: Dementia and Geriatric Cognitive Disorders
Journal name in source: Dementia and Geriatric Cognitive Disorders
Volume number: 49
Issue number: 6
Start page: 611
End page: 616
Number of pages: 6
ISSN: 1420-8008
Web of Science ID: 000619096200001
PubMed ID: 33592617
Scopus ID: 85100872104
eISSN: 1421-9824

The mini-Addenbrooke’s Cognitive Examination (m-ACE) is a brief cognitive battery that assesses 5 subdomains of cognition (attention, memory, verbal fluency, visuospatial abilities, and memory recall). It is scored out of 30 and can be administered in under 5 min providing a quick screening tool for assessment of cognition. Objectives: We aimed to adapt the m-ACE in Arabic speakers in Egypt and to validate it in dementia patients to provide cutoff scores. Methods: We included 37 patients with dementia (Alzheimer’s disease [n = 25], vascular dementia [n = 8], and dementia with Lewy body [n = 4]) and 43 controls. Results: There was a statistically significant difference (p < 0.001) on the total m-ACE score between dementia patients (mean 10.54 and standard deviation [SD] 5.83) and controls (mean 24.02 and SD 2.75). There was also a statistically significant difference between dementia patients and controls on all sub-score domains of the m-ACE (p < 0.05). Performance on the m-ACE significantly correlated with both the Mini-Mental State Examination (MMSE) and the Addenbrooke’s Cognitive Examination-III (ACE-III). Using a receiver operator characteristic curve, the optimal cutoff score for dementia on the m-ACE total score was found to be 18 (92% sensitivity, 95% specificity, and 94% accuracy). Conclusions: We adapted the m-ACE in Arabic speakers in Egypt and provided objective validation of it as a screening tool for dementia, with high sensitivity, specificity, and accuracy.

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Arabic, Dementia, Egypt

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Last updated on 2021-12-09 at 09:29