Commentary
GAINING MORE INSIGHT INTO THE DETERMINANTS OF CANDIDA SPECIES PATHOGENICITY IN THE ORAL CAVITY


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Publication Details
Author list: Arzmi, M. H.; Alshwaimi, E.; Himratul-Aznita, W. H.; Razak, F. Abdul; Farina, F.; McCullough, M. J.; Cirillo, N.
Publisher: Biolife
Publication year: 2014
Journal: European Journal of Inflammation
Journal name in source: EUROPEAN JOURNAL OF INFLAMMATION
Volume number: 12
Issue number: 2
Start page: 227
End page: 235
Number of pages: 9
ISSN: 1721-727X
Web of Science ID: 000340012800002
PubMed ID:
Scopus ID: 84905864654


Candida infection (candidiasis) is potentially life threatening and can occur in almost all anatomical sites, including the mouth. Candida species are in fact the most common fungal pathogens isolated from the oral cavity and frequently cause superficial infections such as oral candidiasis and denture-associated erythematous stomatitis. Whilst systemic dissemination of Candida from intraoral foci is rare and largely due to severe deficits of the host immune defenses, the development of localized oral candidiasis is most commonly related to a variety of non-immune determinants such as Candida virulence factors and permissive oral microenvironment. In particular, phenotypic switching and dental biofilm have emerged as major determinants for the pathogenicity of Candida and are currently the subject of intense research. An understanding of the molecular aspects underlying the biological behavior of Candida will be the key to the development of effective preventive as well as therapeutic measures for invasive and oral candidiasis.

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Keywords
dental biofilm, oral candidiasis, phenotypic switching, virulence factors

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Last updated on 2018-02-01 at 15:12