Journal article
A novel approach to produce monodisperse hollow pure silica spheres


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Publication Details
Author list: Sultan Akhtar, Şeyda Tuğba Günday, B. Rabindran Jermy, M. A. Almessiere and Ayhan Bozkurt
Publisher: Elsevier
Publication year: 2019
Journal: Journal of Saudi Chemical Society
Journal name in source: Journal of Saudi Chemical Society
Volume number: 23
Issue number: 4
Start page: 477
End page: 485
Number of pages: 9
ISSN: 1319-6103
Web of Science ID: 000465566500010
PubMed ID:
Scopus ID: 85054058932
eISSN: 1319-6103


In this work, we report an efficient method to produce pure hollow silica spheres (HSS) using phenyltrimethoxysilane (PTMS) compound. The production of HSS was carried out via hydrolysis of PTMS in the aqueous media and followed by a condensation reaction to form silica spheres with phenyl groups. The product was then calcined to remove phenyl groups and obtain pure silica spheres with >95% fine structure. The chemical nature of pure silica was confirmed by Fourier transforms infrared spectroscopy. The calcined HSS were stable beyond the temperature of 900 °C as confirmed by thermal gravimetric analysis (TGA). The calcined spheres preserved their spherical appearance and hollow core as shown by SEM and TEM micrographs. Interestingly, the average size of the spheres was reduced significantly after calcination from 760 to 510 nm, confirming further the removal of phenyl groups. The calcined HSS offered much higher surface area (As) when analysed by BET; Asfor calcined product was ∼406 and mere ∼4.8 m2/g for uncalcined HSS. Finally, drug release study of cisplatin/HSS showed over 45% of steady cumulative release for 72 h. The prepared HSS can be dispersed in water opening the possibility of many novel bio/non-bio applications.


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Last updated on 2019-06-11 at 09:10