Poster
GASTRIC FLOATING MICROSPONGE


Research Areas
Currently no objects available

Publication Details
Subtitle: A NOVEL APPROACH TO AMELIORATE THERAPEUTIC RESPONSE AND ALLIVIATE UNTOWARD EFFECTS OF STOMACH SPECIFIC DRUGS
Author list: Alshahrani A, KHALID M, MOHSIN A, Alqarni A, Alkhateeb F, Jafar M
Publication year: 2019
Web of Science ID:
PubMed ID:
Scopus ID:


Microparticulate drug delivery systems such as microspheres, micro-beads, minitabs, etc have gained more popularity in the pharmaceutical field. They allow the improvement of drug clinical response and the alleviation of side effects. In this context, microsponges represent a novel entity of porous polymeric microspheres, which allow the entrapment of a wide variety of drugs. These novel porous carriers could be used as a strategy for modulation of the drug release, increasing the bioavailability and therapeutic response and, at the same time, reducing the side effects. In oral administration, these can happen with pH variations, for drug that due to be released at a specific site, and prolonging of gastric retention time, especially to drugs absorbed mainly in the stomach or in the proximal part of the small intestine. Microsponges hold certification as one of the potential approaches for gastric retention. Microsponges are porous spherical empty particles without core and can remain in the gastric region for delayed periods. They significantly increase the gastric residence time of medication, thereby enhance bioavailability, improves patient compliance by reducing dosing frequency, lessen the medication loss, enhance retention of medication which solubilize only in stomach, enhance solubility for medications that are poorly soluble at a higher pH environment. One of the major advantages of microsponge over other microparticulate systems is its high drug loading capacity. In the present review article published reports on gastric floating microsponge of drugs with special emphasis on method of preparation, characterization, and in-vitro and in-vivo evaluation are discussed. The electronic databases such as Web of Science, Google Scholar, E-Resource Portal of Imam Abdulrahman bin Faisal University, Dammam, Scopus, PubMed, Springer Link, etc. also published books were used to gather all related information about Gastric floating microsponge


Projects
Currently no objects available

Keywords
Currently no objects available

Documents
Currently no objects available

Last updated on 2019-28-04 at 09:36